Quantifying circulating cell-free DNA as clinical biomarker
نویسندگان
چکیده
منابع مشابه
Cell-free circulating tumor DNA analysis for breast cancer and its clinical utilization as a biomarker
Circulating tumor DNA (ctDNA) in the blood of cancer patients contains much information on genetic and epigenetic profiles associated with cancer development, progression, and response to therapy. Analysis of ctDNA provides an opportunity for non-invasive sampling of tumor DNA repetitiously and therefore advance precision medicine. Recent development in massively parallel sequencing and digital...
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cell free dnas (cfdnas) are small fragments of genomic or mitochondrial dna releasing from cells into the blood stream. the presence of cfdna in the human circulatory system has been shown for the first time in 1948 however, the potential clinical applications of cfdna remained unknown until recent progress in detection and quantification of these molecules by sensitive methods. in this paper, ...
متن کاملCirculating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer
Circulating cell-free DNA (cfDNA), which can be obtained from plasma or serum by non-invasive procedures, has showed great potential to predict treatment response and survival for cancer patients. Several studies have assessed the prognostic and predictive value of cfDNA in non-small cell lung cancer (NSCLC). However, these studies were often small and reported varying results. To address this ...
متن کاملCirculating cell-free DNA content as blood based biomarker in endometrial cancer
Background Altered circulating cell-free DNA (cfDNA) levels are related to cancer development and aggressiveness. Up to now, very few studies have been performed for evaluating cfDNA content in endometrial cancer (EC). Methods First, we measured cfDNA release in blood serum of EC cancer patients collected before surgery and before the beginning of any treatment by SYBR Gold assay and correlat...
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Cardiovascular (CV) disease remains a major cause of mortality and morbidity worldwide, a widely spread illness worldwide and associated with increasing mortality within last decades [1]. Therefore, the high burden of CV and metabolic risk factors in different countries may have been affected the increased incidences of death in subjects prior to documentation of CV disease. In this context, it...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2018
ISSN: 0923-7534
DOI: 10.1093/annonc/mdy269.157